Physical Activity Alters Inflammation in Older Adults by Different Intensity Levels

Purpose To examine the influence of reallocating time spent at different objectively measured physical activity (PA) behaviors on markers of systemic inflammation in older women with different levels of metabolic risk. Methods Accelerometer-based monitoring of PA was conducted in a population of community-dwelling older women (n = 111; age, 65–70 yr) for determination of daily sedentary time, time in light PA (LPA) and moderate-to-vigorous PA (MVPA). Blood samples were collected for the assessment of the systemic inflammatory markers C-reactive protein (CRP), fibrinogen, and adiponectin. Metabolic risk was assessed by standardized procedures based on definitions for the metabolic syndrome. Data were analyzed by linear regression models based on isotemporal substitution analysis. Results Reallocating 30 min of sedentary time with either time in LPA (β = −0.47; P

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