Automated Mechanical Peripheral Stimulation Effects on Gait Variability in Individuals With Parkison’s Disease and Freezing of Gait: A Double-Blind, Randomized Controlled Trial (Ms. Ref. No.: ARCHIVES-PMR-D-18-00162)

Publication date: Available online 11 June 2018
Source:Archives of Physical Medicine and Rehabilitation
Author(s): Ana Francisca Rozin Kleiner, Aline de Souza Pagnussat, Camila Pinto, Ritchele Rovido, Ana Paula Salazar, Manuela Galli
Objectiveto assess the effects of Automated Peripheral Stimulation (AMPS) in reducing gait variability of subjects with Parkinson's Disease (PD) and freezing of gait (FOG) treated with AMPS and to explore the effects of this treatment on gait during a single task (walking) and a dual task (walking while attending the word-color Stroop test).Designinterventional, double-blinded, placebo-controlled, randomized trial.SettingClinical rehabilitation.ParticipantsThirty subjects were randomized into two groups: AMPS (n=15) and AMPS SHAM (n=15).InterventionsBoth groups received two treatment sessions a week for 4 consecutive weeks (totaling 8 treatment sessions). AMPS was applied by using a medical device (Gondola™) and consisted in mechanical pressure stimulations delivered by metallic actuators on four areas of the feet. Treatment parameters and device configuration were modified for AMPS SHAM group.Main Outcome MeasuresGait analyses were measured at baseline and after the 1^st, 4^th, and 8^th treatment sessions.ResultsInteractions among groups and sessions were found for both conditions while off anti-parkinsonian medications. AMPS decreased gait variability in subjects with PD and FOG for both single and dual task conditions.ConclusionsAMPS is an effective add-on therapy for treating gait variability in patients with PD and FOG.



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