Παρασκευή 23 Φεβρουαρίου 2018

Sodium-potassium pump assessment by submaximal electrical nerve stimulation

elsevier-non-solus.png

Publication date: April 2018
Source:Clinical Neurophysiology, Volume 129, Issue 4
Author(s): Steven Hageman, Maria O. Kovalchuk, Boudewijn T.H.M. Sleutjes, Leonard J. van Schelven, Leonard H. van den Berg, Hessel Franssen
ObjectiveSodium-potassium pump dysfunction in peripheral nerve is usually assessed by determining axonal hyperpolarization following maximal voluntary contraction (MVC) or maximal electrical nerve stimulation. As MVC may be unreliable and maximal electrical stimulation too painful, we assessed if hyperpolarization can also be induced by submaximal electrical nerve stimulation.MethodsIn 8 healthy volunteers different submaximal electrical stimulus trains were given to the median nerve at the wrist, followed by 5 min assessment of thresholds for compound muscle action potentials of 20%, 40% or 60% of maximal.ResultsThreshold increase after submaximal electrical nerve stimulation was most prominent after an 8 Hz train of at least 5 min duration evoking submaximal CMAPs of 60%. It induced minimal discomfort and was not painful. Threshold increase after MVC was not significantly higher than this stimulus train.ConclusionsSubmaximal electrical stimulation evokes activity dependent hyperpolarization in healthy test subjects without causing significant discomfort.SignificanceSodium-potassium pump function may be assessed using submaximal electrical stimulation.



from Physiology via xlomafota13 on Inoreader http://ift.tt/2ELDswg
via IFTTT

Δεν υπάρχουν σχόλια:

Δημοσίευση σχολίου

Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.