Role of CTCF in DNA Damage Response

Publication date: Available online 23 February 2018
Source:Mutation Research/Reviews in Mutation Research
Author(s): Vinay Singh Tanwar, Cynthia C. Jose, Suresh Cuddapah
CCCTC-binding factor (CTCF) is a highly conserved, ubiquitously expressed zinc finger protein. CTCF is a multifunctional protein, associated with a number of vital cellular processes such as transcriptional activation, repression, insulation, imprinting and genome organization. Emerging evidence indicates that CTCF is also involved in DNA damage response. In this review, we focus on this newly identified role of CTCF in facilitating DNA double-strand break repair. Due to the large number of cellular processes in which CTCF is involved, factors that functionally affect CTCF could have serious implications on genomic stability. It is becoming increasingly clear that exposure to environmental toxicants could have adverse effects on CTCF functions. Here we discuss the various ways that the environmental toxicants could impact CTCF functions and the potential consequences on DNA damage response.



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