Τρίτη 12 Δεκεμβρίου 2017

Improved detection of synthetic lethal interactions in Drosophila cells using variable dose analysis (VDA) [Genetics]

Synthetic sick or synthetic lethal (SS/L) screens are a powerful way to identify candidate drug targets to specifically kill tumor cells, but this approach generally suffers from low consistency between screens. We found that many SS/L interactions involve essential genes and are therefore detectable within a limited range of knockdown...

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