Purpose: To investigate potential sex-related differences on spontaneous cardiac baroreflex sensitivity (cBRS) following acute isometric handgrip (IHG) exercise. Methods: Twenty men (23+/-3 years) and 20 women (24+/-4 years) randomly performed four sets of 2-min IHG exercise (two sets for each limb) at 30% maximum voluntary contraction (MVC - experimental) or 3% MVC (sham). Beat-to-beat heart rate (HR) and arterial blood pressure (BP) were monitored using finger photoplethysmography before and 10-, 20-, and 30-min following IHG. Spontaneous cBRS was assessed via the sequence technique and cardiac autonomic modulation via time- and frequency-domain HR variability. Results: Following IHG, spontaneous cBRS increased during 10-min of recovery in men ([INCREMENT]13+/-5%, P=0.03 vs. rest) and increased further in women ([INCREMENT]23+/-4%, P
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