Τρίτη 14 Νοεμβρίου 2017

DNA-RNA interactions are critical for chromosome condensation in Escherichia coli [Genetics]

Bacterial chromosome (nucleoid) conformation dictates faithful regulation of gene transcription. The conformation is condition-dependent and is guided by several nucleoid-associated proteins (NAPs) and at least one nucleoid-associated noncoding RNA, naRNA4. Here we investigated the molecular mechanism of how naRNA4 and the major NAP, HU, acting together organize the chromosome structure...

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