P 133 Differentiating hypo- and hyperaroused fatigue in major depression and in the context of organic diseases

Fatigue is a core symptom in patients with major depressive disorder (MDD), and a common symptom in organic diseases involving inflammatory and immunological processes. From a clinical perspective, fatigue in depression is a state with high inner tension and prolonged sleep onset latencies, whereas fatigue in the context of organic diseases describes an anergic state with excessive sleepiness and short sleep latencies. Given that these two states are diametrically opposed in the arousal dimension, it has been proposed to differentiate two subtypes of fatigue (Hegerl et al., 2013; Hegerl and Ulke, 2016): hyperaroused fatigue (typical for depression) and hypoaroused fatigue (typical in the context of organic diseases).

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