FV 2 Reduced spatial variability in cortical working memory networks after macro-anatomical alignment – Converging evidence from multiple fMRI studies

Reducing the spatial variability in group analyses is an important issue in functional neuroimaging studies. Commonly volume-based whole-brain alignment procedures are used to provide a common analysis space and to align brains across subjects. Inter-individual differences in the cortical folding pattern are an important source of spatial variability. However, volume based alignment methods do not take this factor into account. By contrast, surface based alignment procedures have been shown to significantly improve macro-anatomical alignment and increase the overlap of functional activation.

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