FV 1 In vivo staging in ALS – A mono-centric cross-sectional and longitudinal DTI-based study

Neuropathological studies in amyotrophic lateral sclerosis (ALS) have shown that ALS may disseminate in a regional sequence in four disease-related patterns (Braak et al., 2013). Recently, our group reported the diffusion tensor imaging (DTI)-based analysis of sequential spreading of disease in ALS (Kassubek et al., 2014; Müller et al., 2016). The aim of this study was to show that longitudinal data support the pathological findings and to establish DTI as an in vivo tool to image pathological ALS stages by testing for longitudinal consistency of the categorization results.

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