Transcriptional mutagenesis (TM) due to misincorporation during RNA transcription can result in mutant RNAs, or epimutations, that generate proteins with altered properties. TM has long been hypothesized to play a role in aging, cancer, and viral and bacterial evolution. However, inadequate methodologies have limited progress in elucidating a causal association....
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Τρίτη 29 Αυγούστου 2017
Accurate RNA consensus sequencing for high-fidelity detection of transcriptional mutagenesis-induced epimutations [Genetics]
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