Potential Association of IL1B Polymorphism with Iron Deficiency Risk in Childhood Helicobacter pylori Infection.

Objective: Helicobacter pylori (H. pylori) infection occurs predominantly in childhood. Host immune response gene polymorphism is reported to affect the susceptibility to H. pylori infection and the outcome of H. pylori-related gastric cancer. However, not all H. pylori-infected patients exhibit iron deficiency. The relationship between host genetic polymorphisms and iron deficiency mediated by H. pylori infection is not well understood. Methods: Subjects (n = 644) from the general population aged 10 to 18 years were divided into two groups based on serology testing for anti-H. pylori IgG: (1) seropositive study group; (2) seronegative control group. Five single nucleotide polymorphisms (SNPs) in IL1B (rs1143627 and rs16944), IL8 (rs4073), IL10 (rs1800896), and ABO (rs505922), were genotyped and the iron status of the two groups was compared. Results: The seroprevalence rate for H. pylori was 10.7% in this study. Infected subjects were significantly older and had lower serum iron levels than uninfected subjects (P = 0.0195 and 0.0059, respectively). Multivariate analysis revealed a significantly higher frequency of the T allele of rs505922 (OR = 6.128; P

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