Source:Clinical Neurophysiology
Author(s): Alonso Zea Vera, Gewalin Aungaroon, Paul S. Horn, Anna W. Byars, Hansel M. Greiner, Jeffrey R. Tenney, Todd M. Arthur, Nathan E. Crone, Katherine D. Holland, Francesco T. Mangano, Ravindra Arya
ObjectiveTo examine current thresholds and their determinants for language and motor mapping with extra-operative electrical cortical stimulation (ECS).MethodsECS electrocorticograph recordings were reviewed to determine functional thresholds. Predictors of functional thresholds were found with multivariable analyses.ResultsIn 122 patients (age 11.9 ± 5.4 years), average minimum, frontal, and temporal language thresholds were 7.4 (± 3.0), 7.8 (± 3.0), and 7.4 (± 3.1) mA respectively. Average minimum, face, upper and lower extremity motor thresholds were 5.4 (± 2.8), 6.1 (± 2.8), 4.9 (± 2.3), and 5.3 (± 3.3) mA respectively.Functional and after-discharge (AD)/seizure thresholds were significantly related. Minimum, frontal, and temporal language thresholds were higher than AD thresholds at all ages. Minimum motor threshold was higher than minimum AD threshold up to 8.0 years of age, face motor threshold was higher than frontal AD threshold up to 11.8 years age, and lower subsequently. UE motor thresholds remained below frontal AD thresholds throughout the age range.ConclusionsFunctional thresholds are frequently above AD thresholds in younger children.SignificanceThese findings raise concerns about safety and neurophysiologic validity of ECS mapping. Functional and AD/seizure thresholds relationships suggest individual differences in cortical excitability which cannot be explained by clinical variables.
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