Τρίτη 13 Δεκεμβρίου 2016

Loss-of-function genetic tools for animal models: cross-species and cross-platform differences

Nature Reviews Genetics 18, 24 (2017). doi:10.1038/nrg.2016.118

Authors: Benjamin E. Housden, Matthias Muhar, Matthew Gemberling, Charles A. Gersbach, Didier Y. R. Stainier, Geraldine Seydoux, Stephanie E. Mohr, Johannes Zuber & Norbert Perrimon

Our understanding of the genetic mechanisms that underlie biological processes has relied extensively on loss-of-function (LOF) analyses. LOF methods target DNA, RNA or protein to reduce or to ablate gene function. By analysing the phenotypes that are caused by these perturbations the wild-type function of



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