MIXED HYDROTROPY: A RISING TOOL FOR SOLUBILITY ENHANCEMENT OF TRANSDERMAL DRUG DELIVERY AND COSMECEUTICAL APPLICATIONS

2016-11-08T01-11-23Z
Source: Indo American Journal of Pharmaceutical Research
Satish Polshettiwar, Snehal Shivaji Khorate*.
Solubility is the important phenomenon in pharmaceutical formulation, which plays very effective and significant role in the designing of various dosage forms. It is important characteristics of a drug for its oral bioavailability, formation and development of different dosage form of different drugs and for quantitative analysis. There are many techniques which are used to enhance the aqueous solubility, hydrotropy is one of them which is simple, advance, cost effective, eco-friendly and novel method. Hydrotropy is defined as a solubilization process whereby addition of a large amount of second solutes results in an increase in the aqueous solubility of another solute and chemicals which are used in the hydrotropy are called hydrotropes like sodium benzoate, sodium citrate, urea, niacinamide etc. To achieve highest degree of solubility hydrotropes can be combined with polymers or cosolvents as in mixed hydrotropy. Mixed hydrotropic solubilization technique is the phenomenon to increase the solubility of poorly water-soluble drugs in the blends of hydrotropic agents which gives synergistic enhancement in solubility. Based on advantages of certain properties like the high selectivity, independent of pH and cheap, easy availability makes this technique more powerful than other Solubilization methods. In the present review attempt has been made to provide detailed information on the novel applications of hydrotropy with respect to Cosmeceutical and transdermal formulations as well the mechanism of hydrotropes, hydrotropic agents, classification and Solubilization of hydrotropes, several hydrotropes used in tablet formulation are discussed.


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