Τρίτη 8 Νοεμβρίου 2016

FORMULATION AND EVALUATION OF EXTENDED RELEASE MATRIX TABLETS OF TENATOPRAZOLE SODIUM USING NATURAL POLYMERS

2016-11-08T01-11-23Z
Source: Indo American Journal of Pharmaceutical Research
B. Divya*, J. Sreekanth, D. Satyavati.
Delayed release dosage forms are the best formulations which are used for drugs that are destroyed in the gastric fluids, or cause gastric irritation, and are absorbed preferentially in the intestine. The stability of Proton pump inhibitors is a function of pH; these are rapidly degraded in acid media, and are stable under alkaline conditions. Therefore exposure of Tenatoprazole sodium to the acidic content of the stomach would lead to significant degradation of the drug and hence, reduced bioavailability. The present investigation is aimed to formulate the matrix tablets of Tenatoprazole sodium with cashew nut tree gum, Okra gum and Xanthum gum and during formulation of the matrix tablets, granules are prepared with drug and polymers and dried and sieved well and were finally enteric coated with AQOAT AS-MF to prevent the tablets from acidic environment. Then the granules are compressed in to tablets. The tablets were evaluated for preformulation studies like angle of repose, bulk density, compressibility index and physical characteristics like hardness, weight variation, friability and drug content. In-vitro release of drug was performed in phosphate buffer solution pH 6.8 for twelve hours. All the physical characters of the fabricated tablet were within acceptable limits. It is cleared through the dissolution profile of Tenatoprazole sodium matrix tablets prepared using different polymers were indicated an increase in the polymer ratio retarded the drug release to a greater extent as evident from the in vitro drug release profile of batches A-3, B-3 & C-3. Therefore, 50% polymer level was found to be ideal for the matrix system. A better sustained drug release i.e 89.7±0.32 % drug release was obtained with the matrix tablet (Batch B-3) made-up of the Okra gum (Drug: polymer ratio=1:1) than with the cashew nut tree gum and Xanthum gum.


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