The changing profile of coeliac disease in paediatric patients: A 20-year long retrospective study

Coeliac disease (CD) is a systemic immune-mediated disorder causing an injury to the mucosa of the small intestine, with extremely variable symptoms. The aim of the study was to investigate the current clinical presentation of coeliac paediatric patients in order to increase the awareness of this disorder, to improve its diagnostic rate and to identify familiar conditions. The diagnosis, performed on 186 coeliac children from 1994 and July 2015, relied on different algorithms: the earliest patients diagnoses were based on Anti-Gliadin Antibodies and histological evaluation of the intestinal biopsies, while the most recent ones followed the latest 2012 ESPGHAN guidelines.

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