Prevalence of coeliac disease and of HLA predisposition in first degree relatives of coeliac paediatric patients

CD is an autoimmune disorder triggered by gluten which activates an immune reaction against the CD autoantigen, such as tissue transglutaminase (TG2), in genetically predisposed subjects. It has a strong genetic component and the disease incidence is significantly higher among first-degree relatives, with an increasing rate among twin patients. HLA class II genes play a major role in the pathogenesis of this disease, even though other involved genes have been characterized. The aim of the study was the determination of the prevalence of CD and the genetic predisposition for the disease onset in first degree relatives of paediatric coeliac patients.

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