Quick and accurate quantification of the premature brain

The immature brain is selectively vulnerable to injury (Volpe, 2009; Bonaficio et al., 2015) and premature birth places children at increased risk of chronic neurological morbidities including epilepsy, motor impairment, and cognitive delay (Back et al., 2006; Nardou et al., 2013). In spite of the increased risks, acute brain damage can be particularly difficult to identify in premature neonates. Neurological evaluations remain limited because the underdeveloped brain lacks the sophisticated functions that can be easily tested at the bedside and thus provides little prognostic information on cortical development (Yang, 2004).

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