Changes in electrocorticographic beta frequency components precede spreading depolarization in patients with acute brain injury

Spreading depolarization (SD) occurs during the first two weeks after traumatic brain injury (TBI), subarachnoid hemorrhage (SAH), malignant hemispheric stroke (MHS) and intracranial hemorrhage (ICH). In patients with SAH, focal clusters of SDs are observed in brain areas where new ischemia occurs. After SAH and TBI, SDs are associated with DIND (delayed ischemic neurological deficit) and worsened outcome (Dreier et al. 2006; Dreier et al. 2011; Hartings et al. 2011a, Hartings et al. 2011b). In patients with subacute MHS, the incidence of SDs is particularly high (Dohmen et al.

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