ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF PAIN RELIEF HERBAL FORMULATIONS

2016-05-04T19-37-24Z
Source: Indo American Journal of Pharmaceutical Research
Rucha J. Shah, Ajay I. Patel, Kartik V. Vikani, Nisha L. Patel.
A rapid, sensitive, precise, and Robust Gas chromatography(GC) method was developed and validated for the simultaneous estimation of Menthol, Methyl salicylate and Linseed oil in Laboratory prepared pain relief herbal formulation and marketed pain relief formulation. The determination was carried out on capillary gas chromatography using flame ionization detector. Good separation of menthol (tR= 10.368), methyl salicylate (tR= 10.795) and linseed oil (tR= 21.912 and 25.180) and terpene hydrate (tR= 13.914) was obtained. The recovery of Menthol, Methyl Salicylate and Linseed oil was found to be 98.34%, 99.1% and 102.74% respectively. The correlation coefficients of linear regression analysis (r2) were found to be 0.999, 0.999 and 0.996 respectively. Thus Proposed GC method provides a good resolution of Menthol. Methyl salicylate and Linseed oil.


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