Τετάρτη 16 Μαρτίου 2016

The genetics of drug efficacy: opportunities and challenges

Nature Reviews Genetics 17, 197 (2016). doi:10.1038/nrg.2016.12

Authors: Matthew R. Nelson, Toby Johnson, Liling Warren, Arlene R. Hughes, Stephanie L. Chissoe, Chun-Fang Xu & Dawn M. Waterworth

Lack of sufficient efficacy is the most common cause of attrition in late-phase drug development. It has long been envisioned that genetics could drive stratified drug development by identifying those patient subgroups that are most likely to respond. However, this vision has not been realized



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