Τετάρτη 16 Μαρτίου 2016

Electroencephalogram Signatures of Ketamine-Induced Unconsciousness

Ketamine is an N-methyl-D-aspartate (NMDA) receptor antagonist that is used as a dissociative anesthetic (Domino et al., 1965, Corssen et al., 1966), a research model for schizophrenia (Insel, 2010), and a fast acting treatment for major depressive disorder (Zarate et al., 2006). At low doses, ketamine produces a dissociative state characterized by hallucinations, altered sensory perception and analgesia, while at higher doses it induces a state of unconsciousness appropriate for general anesthesia.

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