Estimation of Nucleon D-Term in QCD

Particles doi: 10.3390/particles2030022

Authors: Igor V. Anikin

Using the light-cone sum rules at leading order, we present an approach to perform the preliminary upper estimation for the nucleon gravitational form factor D ( t ) (D-term contribution). Comparison with the experimental data and with the results of different models is discussed.

Current Approaches to Use Cyclodextrins and Mucoadhesive Polymers in Ocular Drug Delivery—A Mini-Review

Scientia Pharmaceutica doi: 10.3390/scipharm87030015

Authors: Bíró Aigner

Ocular drug delivery provides a challenging opportunity to develop optimal formulations with proper therapeutic effects and acceptable patient compliance because there are many restricting factors involved, such as complex anatomical structures, defensive mechanisms, rapid drainage, and applicability issues. Fortunately, recent advances in the field mean that these problems can be overcome through the formulation of innovative ophthalmic products. Through the addition of solubility enhancer cyclodextrin derivatives and mucoadhesive polymers, the permeability of active ingredients is improved, and retention time is increased in the ocular surface. Therefore, preferable efficacy and bioavailability can be achieved. In this short review, the authors describe the theoretical background, technological possibilities, and the current approaches in the field of ophthalmology.

Halogen-Substituted Derivatives of Dictyostelium Differentiation-Inducing Factor-1 Suppress Serum-Induced Cell Migration of Human Breast Cancer MDA-MB-231 Cells in Vitro

Biomolecules doi: 10.3390/biom9070256

Authors: Totsuka Makioka Iizumi Takahashi Oshima Kikuchi Kubohara

Triple-negative breast cancer (TNBC) is highly proliferative and metastatic, and because it lacks three major molecular targets for chemotherapy (estrogen receptor, progesterone receptor, and human epidermal receptor 2), it is extremely refractory. Differentiation-inducing factor 1 (DIF-1) and DIF-3, which are chlorinated alkylphenones, are lead anticancer compounds found in the cellular slime mold Dictyostelium discoideum. Here, we examined the in vitro effects of DIF-1, DIF-3, and 25 DIF derivatives on cell proliferation and serum-induced cell migration in human MDA-MB-231 cells, a model TNBC cell line. We found that Br-DIF-1, a chlorine-to-bromine-substituted derivative of DIF-1, strongly suppressed cell migration (IC50, 3.8 M) with negligible effects on cell proliferation (IC50, >20 M). We then synthesized 18 derivatives of Br-DIF-1 and examined the in vitro effects of these derivatives on cell proliferation and serum-induced cell migration in MDA-MB-231 cells. Among the derivatives, Br-DIF-1(+1), Br-DIF-1(+2), and Br-DIF-3(+2) exhibited strong anti-cell migration activities with IC50 values of 1.5, 1.0, and 3.1 M, respectively, without affecting cell proliferation (IC50, >20 M). These results suggest that these Br-DIF derivatives are good lead compounds for the development of anti-metastatic drugs against TNBC.

Aegean Sea—Challenges and Dilemmas in Management and Planning for Local Development in Fragmented Insular Regions

Heritage doi: 10.3390/heritage2030108

Authors: Yiota Theodora

In an age of network organization and the digital revolution, under conditions of intense international competition alongside a multifaceted economic downturn, a new form of economy is developing, shaped by the learning society and knowledge-based economy. Under exceptionally difficult conditions where, despite all intentions, economic growth remains the main concern, often without terms or criteria, and even at environmental, territorial and socio-economic cost, the issue: Development for whom, where and on what terms remains “open”. In Greece decades-long unquestioning adoption of developmental models in conjunction with a methodically organized diminishment of the territorial dimension has undermined acquis which had been promoted for years as a prerequisite for life, re-introducing to the discussion the issue of how to plan the various levels and categories of territory, protecting the history and physiognomy of place, ensuring local development in terms of social justice and sustainability in an intensely globalised environment. An answer is sought regarding how best to manage human resources and cultural heritage on the basis of territorial/sectoral and social collaborative networks that are supralocal and transnational focusing on the model of “endogenous development”. Based on research experience regarding the Mediterranean and the Aegean, the article aims to underline the absence of a comprehensive island policy in Greece and highlight crucial issues that need to be resolved at the level of developmental and planning choices in order to eliminate instances of downgrading/abandonment of vulnerable remote and insular border regions. The proposals which are formulated are intended to contribute to the debate about a more equal development for islands and insular areas at a critical juncture for Greece.

Factors Influencing Pseudo-Accommodation—The Difference between Subjectively Reported Range of Clear Focus and Objectively Measured Accommodation Range

Vision doi: 10.3390/vision3030034

Authors: Dhallu Sheppard Drew Mihashi Zapata-Díaz Radhakrishnan Iskander Wolffsohn

The key determinants of the range of clear focus in pre-presbyopes and their relative contributions to the difference between subjective range of focus and objective accommodation assessments have not been previously quantified. Fifty participants (aged 33.0 ± 6.4 years) underwent simultaneous monocular subjective (visual acuity measured with an electronic test-chart) and objective (dynamic accommodation measured with an Aston open-field aberrometer) defocus curve testing for lenses between +2.00 to -10.00 DS in +0.50 DS steps in a randomized order. Pupil diameter and ocular aberrations (converted to visual metrics normalized for pupil size) at each level of blur were measured. The difference between objective range over which the power of the crystalline lens changes and the subjective range of clear focus was quantified and the results modelled using pupil size, refractive error, tolerance to blur, and ocular aberrations. The subjective range of clear focus was principally accounted for by age (46.4%) and pupil size (19.3%). The objectively assessed accommodative range was also principally accounted for by age (27.6%) and pupil size (15.4%). Over one-quarter (26.0%) of the difference between objective accommodation and subjective range of clear focus was accounted for by age (14.0%) and spherical aberration at maximum accommodation (12.0%). There was no significant change in the objective accommodative response (F=1.426, p=0.229) or pupil size (F=0.799, p=0.554) of participants for levels of defocus above their amplitude of accommodation. Pre-presbyopes benefit from an increased subjective range of clear vision beyond their objective accommodation due in part to neural factors, resulting in a measured depth-of-focus of, on average, 1.0D.

 Multimodal Technologies and Interaction,

MTI, Vol. 3, Pages 46: Information Processing and Overload in Group Conversation: A Graph-Based Prediction Model

MTI, Vol. 3, Pages 46: Information Processing and Overload in Group Conversation: A Graph-Based Prediction Model Multimodal Technologies and Interaction doi: 10.3390/mti3030046 Authors: Gabriel Murray Based on analyzing verbal and nonverbal features of small group conversations in a task-based scenario, this work focuses on automatic detection of group member perceptions about how well they are making use of available information, and whether they are experiencing information overload....

Multimodal Technologies and Interaction

Fri Jun 28, 2019 03:00

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End-of-Life Care Challenges from Staff Viewpoints in Emergency Departments: Systematic Review

Healthcare doi: 10.3390/healthcare7030083

Authors: Ali J. Alqahtani Geoffrey Mitchell

The hospital emergency department (ED) is the place where people most commonly seek urgent care. The initial diagnosis of an end-of-life (EOL) condition may occur in the ED. In this review we described the challenges; from the staff members’ perspectives, to safe, appropriate, and high quality end-of-life care (EOLC) for people who are diagnosed with non-malignant diseases who present to ED settings internationally. We conducted a systematic review of peer-reviewed literature. PubMed, Scopus, CINAHL, Medline, and Web of Science were searched from 2007 to 2017. In this review the challenges in providing quality EOLC from staff viewpoints, for EOL people who are diagnosed with non-malignant progressive diseases in ED settings, were classified into eight themes: (1) EOLC education and training, (2) ED design, (3) Lack of family support, (4) Work Load, (5) ED staff communication and decision making, (6) EOLC quality in ED, (7) resource availability (time, space, appropriate interdisciplinary personnel) and (8) integrating palliative care (PC) in ED. The formulation of EOLC using this review result may help to improve the quality of life for dying people by providing ED staff with clear guidelines that can guide them in their daily practice

Effect of Sterigmatocystin or Aflatoxin Contaminated Feed on Lipid Peroxidation and Glutathione Redox System and Expression of Glutathione Redox System Regulatory Genes in Broiler Chicken

Antioxidants doi: 10.3390/antiox8070201

Authors: Balogh Kövesi Zándoki Kulcsár Ancsin Erdélyi Dobolyi Bata-Vidács Inotai Szekeres Mézes Kukolya

Authors studied the effect of sterigmatocystin from infected corn (STC), purified sterigmatocystin (PSTC), and aflatoxin B1 from infected corn (AFB1) on lipid peroxidation and glutathione redox parameters, including the expression of their encoding genes in a sub-chronic (14 days) trial. A total of 144 three-week-old cockerels was divided into four experimental groups (n = 36 in each). Control feed was contaminated with STC or PSTC (1590 µg STC/kg or 1570.5 µg STC/kg feed), or with AFB1 (149.1 µg AFB1/kg feed). Six birds from each group were sampled at day 1, 2, 3, 7 and 14 of mycotoxin exposure. As parameters of lipid peroxidation, conjugated dienes (CD) and trienes (CT) were measured in the liver, while malondialdehyde (MDA) concentration was determined in blood plasma, red blood cell hemolysate and liver. Reduced glutathione (GSH) concentration and glutathione peroxidase (GPx) activity were determined in the same samples, and expression of glutathione peroxidase 4 (GPX4), glutathione synthetase (GSS) and glutathione reductase (GSR) genes was measured by RT-PCR in the liver. STC, PSTC or AFB1 caused a slight, but not significant, increase in CD and CT levels; however, in the case of MDA, no increase was found in the liver. Glutathione redox system was activated in the liver by AFB1, but less markedly by STC/PSTC. PSTC and AFB1 resulted in a higher expression of GPX4, while GSS expression was down-regulated by AFB1 on day 1, but up-regulated by STC on day 2 and by both mycotoxins on day 7. However, on day 14, GSS expression was down-regulated by PSTC. Expression of GSR was low on day 1 in AFB1 and PSTC groups, but later it was up-regulated by AFB1. The observed changes regarding gene expression strengthen the hypothesis that the mild oxidative stress, caused by the applied STC doses, activates the glutathione redox system of broiler chickens.

Pharmacy, Vol. 7, Pages 78: A Quantitative Curriculum Mapping of the Faculty of Pharmacy of Yeditepe University, Turkey: A Process to Assess the Consistency of a Curriculum with the Mission and Vision of an Institution and National Requirements

Pharmacy, Vol. 7, Pages 78: A Quantitative Curriculum Mapping of the Faculty of Pharmacy of Yeditepe University, Turkey: A Process to Assess the Consistency of a Curriculum with the Mission and Vision of an Institution and National Requirements Pharmacy doi: 10.3390/pharmacy7030078 Authors: Filiz Esra Önen Bayram Meriç Köksal The changing role of the pharmacist led to some improvements of pharmacy education worldwide these last years. Curricula have evolved and the content-based education...

Pharmacy

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Indirect Chronic Effects of an Oleuropein-Rich Olive Leaf Extract on Sucrase-Isomaltase In Vitro and In Vivo

Nutrients doi: 10.3390/nu11071505

Authors: Alison Pyner Shuk Yan Chan Sarka Tumova Asimina Kerimi Gary Williamson

Consumption of dietary bioactives is an avenue to enhancing the effective healthiness of diets by attenuating the glycaemic response. The intestinal brush border enzyme sucrase-isomaltase (SI) is the sole enzyme hydrolysing consumed sucrose, and we previously showed the acute effects of olive leaf extract (OLE) on sucrase activity when given together with sugars both in vitro and in vivo. Here we tested whether OLE could affect sucrase expression when pre-incubated chronically, a “priming” effect not dependent on competitive interaction with SI, in both a cell model and a human intervention. Using differentiated Caco-2/TC7 cells, long-term pre-treatment with oleuropein-rich olive leaf extract (OLE) lowered SI mRNA, surface protein and activity, and attenuated subsequent sucrose hydrolysis. Based on these results, a randomised, double-blinded, placebo-controlled, crossover pilot study was conducted. OLE (50 mg oleuropein) was consumed in capsule form 3 times a day for 1 week by 11 healthy young women followed by an oral sucrose tolerance test in the absence of OLE. However this treatment, compared to placebo, did not induce a change in post-prandial blood glucose maximum concentration (Glcmax), time to reach Glcmax and incremental area under the curve. These results indicate that changes in SI mRNA, protein and activity in an intestinal cell model by OLE are not sufficient under these conditions to induce a functional effect in vivo in healthy volunteers.

Dentistry Journal, Vol. 7, Pages 70: Chemical, Clinical and Histomorphometric Comparison between Equine Bone Manufactured through Enzymatic Antigen-Elimination and Bovine Bone Made Non-Antigenic Using a High-Temperature Process in Post-Extractive Socket Grafting. A Comparative Retrospective Clinical Study

Dentistry Journal, Vol. 7, Pages 70: Chemical, Clinical and Histomorphometric Comparison between Equine Bone Manufactured through Enzymatic Antigen-Elimination and Bovine Bone Made Non-Antigenic Using a High-Temperature Process in Post-Extractive Socket Grafting. A Comparative Retrospective Clinical Study Dentistry Journal doi: 10.3390/dj7030070 Authors: Danilo Alessio Di Stefano Terry Zaniol Lorenzo Cinci Laura Pieri Enzyme-deantigenic equine bone (EDEB) and anorganic bovine...

Dentistry Journal

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Dentistry Journal, Vol. 7, Pages 68: Factors Associated with Dental Fear and Anxiety in Children Aged 7 to 9 Years

Dentistry Journal, Vol. 7, Pages 68: Factors Associated with Dental Fear and Anxiety in Children Aged 7 to 9 Years Dentistry Journal doi: 10.3390/dj7030068 Authors: Andreas Dahlander Fernanda Soares Margaret Grindefjord Göran Dahllöf The aim was to investigate changes in dental fear and anxiety (DFA) and verify factors associated with DFA in children. A longitudinal cohort study that included 160 children aged 7 years was carried out. A questionnaire was completed by parents...

Dentistry Journal

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Dietary Flavonoids for Immunoregulation and Cancer: Food Design for Targeting Disease

Antioxidants doi: 10.3390/antiox8070202

Authors: Ahn-Jarvis Parihar Doseff

Flavonoids, one of the most abundant phytochemicals in a diet rich in fruits and vegetables, have been recognized as possessing anti-proliferative, antioxidant, anti-inflammatory, and estrogenic activities. Numerous cellular and animal-based studies show that flavonoids can function as antioxidants by preventing DNA damage and scavenging reactive oxygen radicals, inhibiting formation of DNA adducts, enhancing DNA repair, interfering with chemical damage by induction of Phase II enzymes, and modifying signaling pathways. Recent evidence also shows their ability to regulate the immune system. However, findings from clinical trials have been mixed with no clear consensus on dose, frequency, or type of flavonoids best suited to elicit many of the beneficial effects. Delivery of these bioactive compounds to their biological targets through “targeted designed” food processing strategies is critical to reach effective concentration in vivo. Thus, the identification of novel approaches that optimize flavonoid bioavailability is essential for their successful clinical application. In this review, we discuss the relevance of increasing flavonoid bioavailability, by agricultural engineering and “targeted food design” in the context of the immune system and cancer.

Some examples of foods that contain flavonoids are described below: Citrus fruits Citrus fruits such as lemons and oranges contain flavonoids such as hesperidin, quercitrin and rutin. Hesperidin is a glycoside of hesperetin which is a flavanone, and quercitrin and rutin are glycosides of quercetin, which is a flavonol. Another flavonoid found in citrus fruits is tangeritin. Green and white tea Green tea is rich in flavonoids that posses antioxidant properties, which can protect against heart disease and cancer. Some of the important flavonoids in green tea include kaempferol and catechins such as epicatechin, epicatechin gallate, and epigallocatechin gallate. When oolong tea or black tea is prepared, the leaves are allowed to oxidize. This causes conversion of some or all of the catechins to larger molecules and reduces the flavonoid content. White tea is tea that has undergone even less processing than green tea and therefore provides the highest catechin content. Red wine Wine is prepared from grapes, the skins of which are known to contain significant amounts of flavonoids and other polyphenols. The flavonoids are mainly stripped from the stems, skins and seeds of the grape during the wine making process. Red and white wine both contain flavonoids but red wine contains more flavonoids since less contact is made with the skins of white grapes during winemaking. Dark chocolate Flavonoids occur naturally in chocolate but are often extracted because they can taste bitter. Flavonoids are also present in both dark and milk chocolate, although milk can disrupt their absorption. Some examples of other foods that contain flavonoids include: Seabuckthorn Berries, particularly blueberries Onions Parsley Ginkgo biloba Lentils and pulses Sources http://mimoza.marmara.edu.tr/~ozan.deveoglu/A11.pdf http://www.fc.up.pt/pessoas/lfguido/Design/Assets/Flavonoids.pdf http://www.ipharmsciencia.com/Dacuments/1/4.pdf http://ajcn.nutrition.org/content/74/4/418.abstract

Antioxidants, Vol. 8, Pages 202: Dietary Flavonoids for Immunoregulation and Cancer: Food Design for Targeting Disease

Antioxidants, Vol. 8, Pages 202: Dietary Flavonoids for Immunoregulation and Cancer: Food Design for Targeting Disease Antioxidants doi: 10.3390/antiox8070202 Authors: Ahn-Jarvis Parihar Doseff Flavonoids, one of the most abundant phytochemicals in a diet rich in fruits and vegetables, have been recognized as possessing anti-proliferative, antioxidant, anti-inflammatory, and estrogenic activities. Numerous cellular and animal-based studies show that flavonoids can function as...

Antioxidants

Sat Jun 29, 2019 03:00

Antioxidants, Vol. 8, Pages 201: Effect of Sterigmatocystin or Aflatoxin Contaminated Feed on Lipid Peroxidation and Glutathione Redox System and Expression of Glutathione Redox System Regulatory Genes in Broiler Chicken

Antioxidants, Vol. 8, Pages 201: Effect of Sterigmatocystin or Aflatoxin Contaminated Feed on Lipid Peroxidation and Glutathione Redox System and Expression of Glutathione Redox System Regulatory Genes in Broiler Chicken Antioxidants doi: 10.3390/antiox8070201 Authors: Balogh Kövesi Zándoki Kulcsár Ancsin Erdélyi Dobolyi Bata-Vidács Inotai Szekeres Mézes Kukolya Authors studied the effect of sterigmatocystin from infected corn (STC), purified...

Antioxidants

Fri Jun 28, 2019 03:00

Induction of Broad and Polyfunctional HIV-1-Specific T Cell Responses by the Multiepitopic Protein TMEP-B Vectored by MVA Virus

Vaccines doi: 10.3390/vaccines7030057

Authors: Beatriz Perdiguero Cristina Sánchez-Corzo Carlos Oscar S. Sorzano Pilar Mediavilla Lidia Saiz Mariano Esteban Carmen Elena Gómez

A human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) vaccine able to induce long-lasting immunity remains a major challenge. We previously designed a T cell multiepitopic immunogen including protective conserved epitopes from HIV-1 Gag, Pol and Nef proteins (TMEP-B), that induced potent HIV-1-specific CD8 T cells when vectored by DNA and combined with the vaccine candidate modified vaccinia virus Ankara (MVA)-B. Here, we described the vectorization of TMEP-B in MVA (MVA-TMEP) and evaluated the T cell immunogenicity profile elicited in mice when administered in homologous (MVA/MVA) or heterologous (DNA/MVA) prime/boost vector regimens or using homologous or heterologous inserts. The heterologous vector regimen was superior to the homologous protocol in inducing T cell responses. DNA-TMEP-primed animals boosted with MVA-TMEP or MVA-B exhibited the highest magnitudes of HIV-1-specific CD8, CD4 and T follicular helper (Tfh) cells, with MVA-TMEP significantly expanding Gag-specific CD8 T cell responses. In the homologous vector regimen, all groups exhibited similar HIV-1-specific CD8 and CD4 T cell responses, but both MVA-B/MVA-B and MVA-TMEP/MVA-TMEP combinations elicited higher Gag-Pol-Nef (GPN)-specific CD8 T cell responses compared to MVA-TMEP/MVA-B. Our results revealed an enhanced induction of HIV-1-specific T cell responses by TMEP-B when vectored in both DNA and MVA, and supported their use in combined prime/boost strategies for HIV-1 prevention and/or therapy.

Comparative Evaluation of Endotoxin Activity Level and Various Biomarkers for Infection and Outcome of ICU-Admitted Patients

Biomedicines doi: 10.3390/biomedicines7030047

Authors: Toshiaki Ikeda Hidenobu Kamohara Shingo Suda Takeo Nagura Mikiko Tomino Masatoshi Sugi Zen’ichiro Wajima

Here, we concurrently measured the endotoxin activity (EA) level and levels of multiple biomarkers in patient blood obtained within 24 h after being admitted into the intensive care unit (ICU) and analyzed whether there were links between these markers and their associations with patient conditions and outcomes. The EA levels highly correlated with disease severity and patient survival, and showed a significant positive association with levels of lactate, procalcitonin, presepsin, and interleukin-6. Notably, the EA level was the marker that most highly correlated with the results of blood culture, and the presepsin level was the marker most highly correlated with the survival outcome at 28 days. Thus, the optimal biomarker should be selected based on whether it will be used to discriminate the presence of an infection or to predict survival.

Progressive, diffuse, and severe gingival hypertrophy

Zimmermann-Laband-1 Syndrome: Clinical, Histological, and Proteomic Findings of a 3-Year-Old Patient with Hereditary Gingival Fibromatosis

Biomedicines doi: 10.3390/biomedicines7030048

Authors: Federica Guglielmi Edoardo Staderini Federica Iavarone Laura Di Tonno Patrizia Gallenzi

Background: Zimmermann-Laband-1 syndrome (ZLS-1; OMIM# 135500) is a rare genetic disorder whose oral pathognomonic sign is the development of progressive, diffuse, and severe gingival hypertrophy. Most children with abnormally gingival hyperplasia may also present multiple unerupted teeth and skeletal deformities of maxillary arches (i.e., skeletal anterior open bite). Despite phenotypic variability of the clinical spectrum, gingival fibromatosis is the hallmark of ZLS-1. Method: In this study, we report a 3-year-old male patient with a ZLS-1-related gingival overgrowth and failure of eruption of the deciduous teeth in the molar area. Surgical excision was performed under general anesthesia. Results: At three weeks follow-up, esthetics was significantly improved in terms of gingival appearance, and teeth eruption allowed an adequate masticatory function. Conclusion: In severe cases, surgical removal of the hyperplasic fibrous tissue may be required to expose unerupted teeth and establish a proper gingival contour. Surgical excision under general anesthesia is an elective procedure for patients with special needs, mental disability, as well as young and adult patients with dental anxiety type II and IV associated with poor oral health.

Biomedicines, Vol. 7, Pages 48: Zimmermann-Laband-1 Syndrome: Clinical, Histological, and Proteomic Findings of a 3-Year-Old Patient with Hereditary Gingival Fibromatosis

Biomedicines, Vol. 7, Pages 48: Zimmermann-Laband-1 Syndrome: Clinical, Histological, and Proteomic Findings of a 3-Year-Old Patient with Hereditary Gingival Fibromatosis Biomedicines doi: 10.3390/biomedicines7030048 Authors: Federica Guglielmi Edoardo Staderini Federica Iavarone Laura Di Tonno Patrizia Gallenzi Background: Zimmermann-Laband-1 syndrome (ZLS-1; OMIM# 135500) is a rare genetic disorder whose oral pathognomonic sign is the development of progressive, diffuse,...

Biomedicines

Sat Jun 29, 2019 03:00

Biomedicines, Vol. 7, Pages 47: Comparative Evaluation of Endotoxin Activity Level and Various Biomarkers for Infection and Outcome of ICU-Admitted Patients

Biomedicines, Vol. 7, Pages 47: Comparative Evaluation of Endotoxin Activity Level and Various Biomarkers for Infection and Outcome of ICU-Admitted Patients Biomedicines doi: 10.3390/biomedicines7030047 Authors: Toshiaki Ikeda Hidenobu Kamohara Shingo Suda Takeo Nagura Mikiko Tomino Masatoshi Sugi Zen’ichiro Wajima Here, we concurrently measured the endotoxin activity (EA) level and levels of multiple biomarkers in patient blood obtained within 24 h after being admitted...

Biomedicines

Sat Jun 29, 2019 03:00

Chronic Pruritus Responding to Dupilumab—A Case Series

Medicines doi: 10.3390/medicines6030072

Authors: Zhai Savage Qiu Jin Valdes-Rodriguez Mollanazar

Background: Chronic pruritus is defined as itch lasting for greater than six weeks. Pruritus is a burdensome manifestation of several internal and external disease states with a significant impact on quality of life. Dupilumab has shown promise in treating a number of conditions including atopic dermatitis (AD) and asthma. Its success in reducing pruritus in AD has generated interest regarding its potential application in other pruritic conditions, such as chronic pruritus of unknown origin, uremic pruritus, and pruigo nodularis. Methods: In this retrospective analysis, we present a series of 20 recalcitrant pruritus patients seen at a tertiary center treated with off-label dupilumab at standard AD dosing. Results: Dupilumab was successful at reducing itch in all treated patients, leading to complete resolution in 12/20 patients and an overall mean NRSi reduction of 7.55. Dupilumab was well tolerated with no significant adverse effects. Conclusions: Our case series suggests dupilumab may be a safe and efficacious therapeutic option in several pruritic conditions and demonstrates the need for further studies to better ascertain its place in the pruritus treatment armamentarium.

https://www.sanofi.gr/-/media/.../One.../dupilumab-16may.pdf

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Θετικά αποτελέσματα με το Dupilumab σε εφήβους με. ανεπαρκώς ελεγχόμενη μέτρια έως σοβαρή ατοπική δερματίτιδα σε μελέτη Φάσης 3. 

Pathogens, Vol. 8, Pages 94: Mechanisms Involved in the Persistence of Babesia canis Infection in Dogs

Pathogens, Vol. 8, Pages 94: Mechanisms Involved in the Persistence of Babesia canis Infection in Dogs Pathogens doi: 10.3390/pathogens8030094 Authors: Schetters Dogs that are infected with Babesia canis parasites usually show severe clinical signs, yet often very few parasites are detectable in the blood circulation. The results showed that large numbers of B. canis-infected red blood cells accumulate in the microvasculature of infected subjects. The initial process leading to the...

Pathogens

Sat Jun 29, 2019 03:00

Microorganisms, Vol. 7, Pages 189: Effect of Different Laser Wavelengths on Periodontopathogens in Peri-Implantitis: A Review of In Vivo Studies

Microorganisms, Vol. 7, Pages 189: Effect of Different Laser Wavelengths on Periodontopathogens in Peri-Implantitis: A Review of In Vivo Studies Microorganisms doi: 10.3390/microorganisms7070189 Authors: Katarzyna Świder Marzena Dominiak Kinga Grzech-Leśniak Jacek Matys Nowadays, many studies are examining the effectiveness of dental lasers in the treatment of peri-implantitis; however, most of them only report periodontal parameter changes. The authors of this review tried...

Microorganisms

Sat Jun 29, 2019 03:00

Microorganisms, Vol. 7, Pages 188: Viability and Composition Validation of Commercial Probiotic Products by Selective Culturing Combined with Next-Generation Sequencing

Microorganisms, Vol. 7, Pages 188: Viability and Composition Validation of Commercial Probiotic Products by Selective Culturing Combined with Next-Generation Sequencing Microorganisms doi: 10.3390/microorganisms7070188 Authors: Mati Ullah Ali Raza Li Ye Zhu Yu The consumption of dietary supplements to treat health complications or to improve overall health conditions has become a globally increasing trend that leads to the development of a large number of health-related novel...

Microorganisms

Sat Jun 29, 2019 03:00

Microorganisms, Vol. 7, Pages 187: An Asymptomatic Patient with Fatal Infertility Carried a Swedish Strain of Chlamydia trachomatis with Additional Deletion in The Plasmid orf1 that Belonged to A Different MLST Sequence Type

Microorganisms, Vol. 7, Pages 187: An Asymptomatic Patient with Fatal Infertility Carried a Swedish Strain of Chlamydia trachomatis with Additional Deletion in The Plasmid orf1 that Belonged to A Different MLST Sequence Type Microorganisms doi: 10.3390/microorganisms7070187 Authors: Feodorova Zaitsev Saltykov Sultanakhmedov Bakulev Ulyanov Motin Here, we present the first case of asymptomatic genital Chlamydial infection caused by the new emerging Chlamydia trachomatis...

Microorganisms

Fri Jun 28, 2019 03:00

Microorganisms, Vol. 7, Pages 186: Multifaceted Applications of Microbial Pigments: Current Knowledge, Challenges and Future Directions for Public Health Implications

Microorganisms, Vol. 7, Pages 186: Multifaceted Applications of Microbial Pigments: Current Knowledge, Challenges and Future Directions for Public Health Implications Microorganisms doi: 10.3390/microorganisms7070186 Authors: Ramesh Vinithkumar Kirubagaran Venil Dufossé Microbial oddities such as versatile pigments are gaining more attention in current research due to their widely perceived applications as natural food colorants, textiles, antimicrobial activities, and...

Microorganisms

Fri Jun 28, 2019 03:00