Deficits of Visuospatial working memory and executive function in single- versus multiple-domain amnestic mild cognitive impairment: a combined ERP and sLORETA study

Publication date: Available online 23 February 2019

Source: Clinical Neurophysiology

Author(s): Lihua Gu, Jiu Chen, Lijuan Gao, Hao Shu, Zan Wang, Duan Liu, Yanna Yan, Shijiang Li, Zhijun Zhang

Abstract

Objective

According to recent criteria of classification, amnestic mild cognitive impairment (aMCI) could be divided into two categories: single-domain aMCI (sd-aMCI) and multiple-domain aMCI (md-aMCI). The difference between sd-aMCI and md-aMCI needs further exploration. The present study aimed to compare deficits in visuospatial working memory (VSWM) and executive function between sd-aMCI versus md-aMCI patients by use of event-related potentials (ERP) and standardized low-resolution brain electromagnetic tomography analysis (sLORETA).

Methods

The ERP data were measured and analyzed in 26 sd-aMCI, 13 md-aMCI patients and 46 healthy elderly controls (HEC) during VSWM and Go/Nogo processes.

Results

During VSWM task, md-aMCI patients showed decreased P300 amplitude compared to HEC and sd-aMCI patients (All p < 0.05). As compared to sd-aMCI, md-aMCI showed a hypoactivation in the right middle frontal gyrus in 1-back task during the P300 time range. During the Go/Nogo task, sd-aMCI and md-aMCI patients showed reduced N200 amplitude, compared to HEC (All p < 0.05). However, md-aMCI patients had decreased N200 amplitude, with respect to sd-aMCI patients. Further, as compared to sd-aMCI patients, md-aMCI patients showed a hypoactivation in the right superior frontal gyrus during the N200 time range.

Conclusions

These findings with a combined ERP and sLORETA study showed more severe deficits in updating operations of WM, detections of the target stimulus and conflict processes in md-aMCI, compared to sd-aMCI patients.

Significance

The present study showed that a combined ERP and sLORETA study during the VSWM and Go/Nogo tasks could distinguish md-aMCI from sd-aMCI.

from Physiology via xlomafota13 on Inoreader https://ift.tt/2VcUqLy
via IFTTT