Acute high intensity interval exercise reduces colon cancer cell growth

Abstract

Purpose: Physical activity is associated with significant reductions in colorectal cancer mortality. However, the mechanisms by which exercise mediates this antioncogenic effect are not clear. Methods: Colorectal cancer survivors completed acute (n = 10) or chronic (n = 10) exercise regimes. An acute high intensity interval exercise session (HIIE; 4 × 4 min at 85–95% peak heart rate) was completed with serum samples collected at baseline, and 0 and 120 minutes post‐exercise. For the 'chronic' intervention, resting serum was sampled before and after 4 weeks (12 sessions) of HIIE. The effect of serum on colon cancer cell growth was evaluated by incubating cells (CaCo‐2 and LoVo) for up to 72 hours and assessing cell number. Results: Serum obtained immediately following HIIE, but not 120 minutes post‐HIIE, significantly reduced colon cancer cell number. Significant increases in serum interleukin‐6 (p = 0.023), interleukin‐8 (p = 0.036) and tumour necrosis factor‐α (p = 0.003) were found immediately following acute HIIE. At rest, short‐term HIIE training did not promote any changes in cellular growth or cytokine concentrations. Conclusions: The acute effects of HIIE and the cytokine flux may be important mediators of reducing colon cancer cell progression. Repetitive exposure to these acute effects may contribute to the relationship between exercise and improved colorectal cancer survival.

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