Simultaneously recorded intracranial and scalp high frequency oscillations help identify patients with poor postsurgical seizure outcome

Around one third of patients with focal epilepsy continue to have seizures even after therapy with several different antiepileptic drugs (Kwan and Brodie 2000). In these patients epilepsy surgery aiming to remove the epileptic focus is a very effective treatment to stop seizures permanently (Rosenow and Lüders 2001). In some patients non-invasive diagnostic such as MRI and long-term EEG do not lead to conclusive results regarding the epileptic focus. In these patients intracranial chronic EEG recording may be used to delineate the seizure onset zone (SOZ) and define which brain areas have to be removed to have a good postsurgical seizure outcome (Diehl and Lüders 2000).

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