Quantifying Brain White Matter Microstructure of People with Lateral Ankle Sprain

Purpose This study aimed to quantify differences in white matter microstructure and static postural control in individuals with and without a previous history of a lateral ankle sprain. Methods Ten participants with a history of a lateral ankle sprain and 10 controls performed 3, 20-second trials of single-leg static balance on a force platform under an eyes-open condition. Resultant sample entropy (SampEn) was used to assess static postural control performance. To assess white matter microstructure, fractional anisotropy (FA) of the superior cerebellar peduncles and corticospinal tracts was quantified using diffusion tensor imaging (DTI). In the case of statistically significant differences in FA, component diffusivities were evaluated, including mean diffusivity, radial diffusivity (RD), and axial diffusivity (AD). Results Significant differences between participants with and without a history of lateral ankle sprains were observed in superior cerebellar peduncle FA and RD. Participants with a history of lateral ankle sprains had significantly lower FA in the superior cerebellar peduncle compared to controls. Participants with a history of lateral ankle sprains also demonstrated higher RD values in the superior peduncle compared to control. Finally, participants with a history of lateral ankle sprains had lower resultant SampEn values compared to controls. Conclusion Findings suggest that microstructural changes in white matter tracts governing postural control, may be biomarkers of central nervous system dysfunction in individuals with a lateral ankle sprain history. Correspondence: Masafumi Terada, College of Sport and Health Science, Ritsumeikan University, Shiga, Japan. mterada@fc.ritsumei.ac.jp No funding was received for this current study. The results of the current study are presented clearly, honestly, and without fabrication, falsification, or inappropriate data manipulation. The results of the present study do not constitute endorsement by ACSM. CONFLICT OF INTEREST: All authors declare that they have no conflict of interest. Accepted for publication November 2018. © 2018 American College of Sports Medicine

from Sports Medicine via xlomafota13 on Inoreader https://ift.tt/2BwQDC7
via IFTTT