Prospective study of clinical, neurophysiological and urodynamic findings in multiple scleosis patients undergoing percutaneous transluminal venous angioplasty

Multiple Sclerosis (MS) is a multifactorial disease (Lucchinetti et al. 2000; Compston and Cole 2008): perivenular inflammation in the white matter followed by demyelination of central nervous fibers, together with axonal loss and neurodegeneration, contribute to affect sensory (somatic, visual, auditory) motor, cognitive and urinary system functions, leading to increase of disability over time. In animal models, demyelination slows down conduction properties of neural pathways and reduces the ability to transmit neural impulses at high frequency; when combined with axonal degeneration, partial or complete conduction blocks may also occur (McDonald and Sears 1970), leading to functional impairment in virtually all sensory and motor domains.

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