Effects of Oxytocin and Thyroliberin on Anxiety in Male White Mice in Social Stress

The effects of intranasal administration of oxytocin and thyroliberin solutions on changes in behavior in rats after moderate social stress were studied. Investigations were carried out on male Wistar rats (n = 100). Animals of experimental group 1 received intranasal oxytocin at a dose of 0.25 IU in 20 μl bilaterally and those of experimental group 2 received thyroliberin at a dose of 10 10 mmol in 10 μl, while control animals received the same volume of physiological saline. Animals were exposed to moderate social stress for 1 h starting 15 min after substance administration. Animals were tested in an elevated plus maze (EPM) after a further 3 h. These experiments showed that administration of oxytocin led to a decrease in the level of anxiety in social stress as compared with controls. Administration of thyroliberin had no effect on stress-induced changes in behavioral parameters.

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