Effects of Derivatives of 3-Hydroxypyridine and Succinic Acid on Stereotypical Behavior and Catalepsy in Mice

The effects of derivatives of 3-hydroxypyridine and succinic acid (emoxypine, Reamberin, and Mexidol) on the state of cerebral dopaminergic processes were studied using catalepsy and stereotypical "verticalization" (climbing) behavior as criteria in experiments on mice. Single doses of emoxypine, Reamberin, and Mexidol at doses equivalent to the therapeutic range for humans were found to potentiate apomorphine-induced stereotypical behavior and to decrease the cataleptogenic effect of haloperidol. All studied derivatives of 3-hydroxypyridine and succinic acid increased spontaneous catalepsy. Emoxypine and Reamberin stimulated spontaneous stereotypical behavior in mice. The intrinsic cataleptogenic activity of the agents studied here correlated negatively with their influences on spontaneous stereotypical behavior. The nature of changes in stereotypical behavior and catalepsy in response to the test compounds provided evidence of an apparent similarity between their effects on dopaminergic processes and the phenotype of the pharmacological action of partial agonists of dopamine receptors.

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