Decreasing subthalamic deep brain stimulation frequency reverses cognitive interference during gait initiation in Parkinson’s disease

Parkinson's disease (PD) is a neurodegenerative disorder due to a loss of nigrostriatal dopaminergic neurons. From a clinical point of view, PD patients present both motor and cognitive deficits. The classical motor triad consists of akinesia, tremor and rigidity. With time, about 50-70% of patients will develop gait and balance disorders and show freezing of gait (FOG) which is characterised by brief episodes of inability to step and lift their feet from the ground or by extremely short steps (Bloem et al., 2004, Nutt et al., 2011).

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