Auditory N100 gating in patients with schizophrenia: A systematic meta-analysis

Several event-related potential (ERP) components have been considered as biological markers for schizophrenia, such as the auditory mismatch negativity (MMN), auditory P50 gating, or P3 (Thibaut et al., 2015). For these ERP components, there has been decade-long clinical research, with first reports of deficiencies in schizophrenia dating back more than 45 years (Roth and Cannon, 1972). Recent meta-analyses suggest relatively large, trait-related deficits in schizophrenia patients, with patients showing smaller MMN and P3 amplitudes, a delayed P3 response, and less efficient P50 gating, as compared to healthy controls (MMN: Erickson et al., 2016; P3: Jeon and Polich, 2003; P50 gating: de Wilde et al., 2007; Patterson et al., 2008).

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