Safety Considerations in Prescription of NSAIDs for Musculoskeletal Pain: A Narrative Review

Non-steroidal anti-inflammatory drugs (NSAIDs) are frequently prescribed for the treatment of painful musculoskeletal conditions. When prescribing oral NSAIDs, clinicians must consider coexisting cardiovascular, cerebrovascular, gastrointestinal and renal disease as oral NSAIDs are associated with a broad spectrum of adverse effects on these systems. The varying safety profiles of NSAIDs can be attributed to differences in the extent to which the drug inhibits cyclooxygenase (COX)-1 versus COX-2 and their potential for drug-drug interactions.

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