The personal and clinical utility of polygenic risk scores

The personal and clinical utility of polygenic risk scores

The personal and clinical utility of polygenic risk scores, Published online: 22 May 2018; doi:10.1038/s41576-018-0018-x

Polygenic risk profiling can lead to actionable outcomes for individuals at high risk of developing a subset of common adult-onset polygenic diseases. The authors review recent studies that have demonstrated the utility of polygenic risk scores for disease risk stratification and their potential impact on early disease detection, prevention, therapeutic intervention and life planning.

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