Evoked potentials predict psychomotor development in neonates with normal MRI after hypothermia for hypoxic-ischemic encephalopathy

Major focus of research on neonatal hypoxic-ischemic encephalopathy (HIE) has been the identification of early markers of severe brain damage and their role in predicting severe neurological outcome. Nowadays, therapeutic hypothermia (TH) for neonatal HIE and redirection of care reduced severe outcomes. The rate of death or moderate/severe disability at 18–24 months of age decreased from 62% to 44% but, cognitive impairment at school age was unaffected (Shankaran et al., 2005; Shankaran et al., 2012; Gluckman et al., 2005; Eicher et al., 2005; Azzopardi et al., 2009, 2014; Simbruner et al., 2010; Zhou et al., 2010; Jacobs et al., 2011).

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