Amyotrophic lateral sclerosis – time for beta testing?

Recognized from the first descriptions of the disease by Charcot and Joffroy in 1869, amyotrophic lateral sclerosis (ALS) involves the progressive degeneration of lower motor neurons (LMN) from the spinal anterior horns and brainstem, combined with loss of upper motor neurons (UMN) from the primary motor cortex and their axonal projections through the corticospinal tract (CST). Diagnosis remains based around clinical findings of UMN and LMN signs in the same symptomatic region, with accurate detection remaining crucial for timely management of this relentlessly progressive disease.

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