Shimazono-Lecture-1. What I have done using TMS techniques

Publication date: May 2018
Source:Clinical Neurophysiology, Volume 129, Issue 5
Author(s): Yoshikazu Ugawa
CMCT, CTX-BST CT, BST-Cv CT, CCCT, CECT: Using brainstem and conus medullaris stimulation in combination with the motor cortical and spinal nerve stimulation, we estimated conduction delays at several segments in CSTs.Cerebellar inhibition of the motor cortex (CBI): Purkinje cell activation by TMS induced a transient motor cortical inhibition. Mechanisms underlying ataxia was studied with this method.Shor interval intracortical inhibition (SICI): We showed the dependency of SICI on the motor cortical TMS pulse directions, which gave us a hint about the mechanisms of SICI. Neuroplasticity induction by QPS: We have introduced quadripulse stimulation (QPS) for steady plasticity induction in human brain. Using this method, we have shown the normal and abnormal motor or sensory cortical plasticity, drug influence on the plasticity, and also mechanisms for speech production, motor sequence learning or other human performances.Treatments by rTMS and combination with other methods: We have shown some clinical beneficial effects in patients with Parkinson's disease by rTMS over supplementary motor cortex or other areas.Spike time dependent spinal cord plasticity: We induced spike timing dependent plasticity at the CST- spinal motor neuron synapses with combination of brainstem stimulation and peripheral nerve stimulation.



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