Source:Clinical Neurophysiology, Volume 129, Issue 5
Author(s): Satoshi Kuwabara
The diagnosis of amyotrophic lateral sclerosis (ALS) requires (1) evidence for extensive upper and lower motor neuron dysfunction, (2) progressive course, and (3) exclusion of other causes of motor neuronal loss. So far, a number of diagnostic criteria for ALS have been proposed, such as El Escorial (1990), revised El Escorial (1998), Awaji (2008), and updated Awaji (2015). According to the frequent revision/proposal criteria, electrodiagnostic criteria for ALS are somewhat confusing. In these criteria, the body motor system are divided into 4 regions; cranial, cervical, thoracic, and lumbosacral, and evidence for upper and lower motor neuron signs in the two or more regions are required for the diagnosis of "probable" ALS. This lecture reviews a history, current status, and perspectives for ALS electrogiagnosis. The diagnostic sensitivity latest version, the updated Awaji criteria is reported to be 73% in a recent systematic review.
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