Prevalence of Anti-tissue Transglutaminase (tTG) Antibodies and Celiac Disease in Children with IBD

ABSTRACTIntroduction:Celiac disease can occur in children with Inflammatory bowel disease (IBD) and poses a diagnostic challenge. We evaluated the presence of anti-tissue transglutaminase (tTG) antibodies and celiac disease among children with IBD.Methods:In a retrospective chart review, we assessed the prevalence of tTG antibodies and celiac disease and compared with a control group of children with gastrointestinal symptoms without IBD.Results:Study population included 130 children with IBD and 257 in the control group. Abnormal tTG levels were found in 6 and 20 patients, respectively (4.6% vs. 7.8%, p = 0.24). One patient with IBD and 12 in the control group had celiac disease (0.8% vs. 4.7%, p = 0.07).Conclusion:False positive tTG can occur in children with IBD. The prevalence of celiac disease is not increased in children with IBD compared with non-IBD children with gastrointestinal symptoms and is similar to that in the general population. Introduction: Celiac disease can occur in children with Inflammatory bowel disease (IBD) and poses a diagnostic challenge. We evaluated the presence of anti-tissue transglutaminase (tTG) antibodies and celiac disease among children with IBD. Methods: In a retrospective chart review, we assessed the prevalence of tTG antibodies and celiac disease and compared with a control group of children with gastrointestinal symptoms without IBD. Results: Study population included 130 children with IBD and 257 in the control group. Abnormal tTG levels were found in 6 and 20 patients, respectively (4.6% vs. 7.8%, p = 0.24). One patient with IBD and 12 in the control group had celiac disease (0.8% vs. 4.7%, p = 0.07). Conclusion: False positive tTG can occur in children with IBD. The prevalence of celiac disease is not increased in children with IBD compared with non-IBD children with gastrointestinal symptoms and is similar to that in the general population. Address correspondence and reprint requests to Dinesh S. Pashankar, MD, MRCP (UK), Associate Professor of Pediatrics, Division of Gastroenterology. Yale University, School of medicine, 333 Cedar street, PO box 208064, LMP 4109, New Haven, CT 06520 (e-mail: Dinesh.pashankar@yale.edu). Received 7 June, 2017 Accepted 1 December, 2017 We report no conflict of interest. The other authors report no conflicts of interest. © 2017 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology,

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