Adherence to the gluten free diet and health related quality of life in an ethnically diverse pediatric population with Celiac Disease

ABSTRACTObjectives:Celiac disease (CD) is an autoimmune disease that requires life-long adherence to a gluten-free diet (GFD). Adherence to the GFD in childhood may be poor and adversely influence health related quality of life (HRQOL). The study purpose was to determine socio-demographic and socio-economic factors influencing adherence to the GFD and HRQOL in a multi-ethnic cohort of youth with CD.Methods:A multi-site (Edmonton, Hamilton, Toronto) study examining child-parent HRQOL in youth with CD (n=243) and /or mild gastrointestinal complaints (GI-CON; n = 148) was conducted. Socio-demographic (age, child-parental age/education/ethnicity/place of birth), anthropometric (weight, height, BMI), disease (diagnosis, age at diagnosis, duration, Marsh score, serology), household characteristics (income, family size, region, number of children/total household size), HRQOL (Peds TM4.0/Kindl and CDDUX), GI Complaints (PedsQLTM:Gastrointestinal Symptom Scale [GSS]) and gluten intake were measured.Results:Younger age (

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