Acute Inflammatory Responses to Exercise in Patients with Abdominal Aortic Aneurysm

ABSTRACT Purpose Inflammation and extracellular matrix degeneration contribute to abdominal aortic aneurysm (AAA) development. We aimed to assess the effect of exercise intensity on circulating biomarkers of inflammation and extracellular matrix degeneration in patients with AAA and healthy older adults. Methods Twenty patients with AAA (74±6y) and twenty healthy males (72±5y) completed moderate-intensity cycling at 40% peak power output (PPO), higher-intensity intervals at 70% PPO, and control (rest) on separate days. Circulating matrix metalloproteinase-9 (MMP-9), transforming growth factor beta 1 (TGF-β1), interleukin-6 (IL-6), IL-10 and tumour necrosis factor alpha (TNF-α) were analysed at rest, and 0 to 90 min post. Results Biomarkers at baseline were similar between groups. IL-6 responses to exercise were similar between groups, with a greater increase in ΔIL-6 after moderate-intensity compared to higher-intensity exercise (P

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