Workplace Strategies to Prevent Sitting-induced Endothelial Dysfunction.

Prolonged sitting induces endothelial dysfunction in healthy young adults which has been demonstrated to be offset by intermittent fidgeting and standing. No information exists on the impact of sitting and endothelial dysfunction in sedentary middle-aged adults, and whether common workplace counter-interventions (i.e. desk-standing/desk-pedaling) mitigate sitting-induced endothelial dysfunction. Purpose: The objective of this study was to examine whether breaking up prolonged sitting with intermittent standing or under-desk pedaling prevents sitting-induced popliteal artery endothelial dysfunction in middle-aged sedentary, overweight/obese office workers. Hypothesis: We tested the hypothesis that sitting-induced leg endothelial dysfunction would be prevented by intermittent standing or desk pedaling. Methods: Thirteen middle-aged, sedentary overweight/obese subjects (10 males, 3 females; age: 38+/-3 yrs; BMI: 29.7+/-2 kg/m2) participated in three separate testing sessions in a randomized order: 1) four hours of uninterrupted sitting; 2) four hours of sitting interrupted with four 10-minute bouts of standing; and 3) four hours of sitting interrupted with four 10-minute bouts of light-intensity desk pedaling. Doppler ultrasound measured popliteal artery flow mediated dilation (FMD), and associated measures (e.g. shear rate, blood velocity) were measured immediately prior to and immediately following each intervention (sit, stand, and desk pedaling). Results: Four hours of uninterrupted sitting induced a significant impairment in popliteal artery FMD (baseline: 3.1+/-0.3%, post: 1.6+/-0.5%, P

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