Effect of Sensitization by Cerebral Antigen on Expression of Synaptophysin in the Sensorimotor Cortex under Conditions of Ischemia and Immunocorrection of its Consequences

In rats sensitized with cerebral antigen, the level of synaptophysin (SYP) expression in the sensorimotor cortex was significantly lower than that in the intact control (on the 13th, 15th, 22nd, and 42nd but not on the 102nd day after sensitization). In preliminarily sensitized animals with experimentally induced acute impairment of cerebrovascular flow, this index in the affected hemisphere was significantly lower than that in the contralateral intact hemisphere (after 3, 10, and 30 days) and that in sensitized animals without such disorders (after 1, 3, 10 and 30 days). The treatment with an immunomodulator, Imunofan, provided a rapid short-lasting (one–two days) increase in the expression of SYP in both affected and contralateral hemispheres; a significant difference of this index in the two hemispheres, however, was preserved during at least 10 days.

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