Τρίτη 24 Οκτωβρίου 2017

The DNA methyltransferase family: a versatile toolkit for epigenetic regulation

The DNA methyltransferase family: a versatile toolkit for epigenetic regulation

Nature Reviews Genetics, Published online: 16 October 2017; doi:10.1038/nrg.2017.80

The DNA methyltransferase (DNMT) family comprises a conserved set of DNA-modifying enzymes. Recent studies have increased our understanding of how DNMT activity is regulated and revealed that, in addition to establishing and maintaining DNA methylation patterns, DNMT enzymes function in transcriptional silencing, transcriptional activation and post-transcriptional regulation.



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