Emerging and evolving concepts in gene essentiality
Nature Reviews Genetics, Published online: 16 October 2017; doi:10.1038/nrg.2017.74
Identifying which genes in a genome are essential for survival has been a long-standing goal of geneticists. This Review discusses our evolving understanding of cellular gene essentiality across diverse organisms. It describes how essentiality is often non-absolute but is instead dependent on the environment or genetic background and how this knowledge can be exploited therapeutically.
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