Effects of Sedentary Aging and Lifelong Exercise on Left Ventricular Systolic Function.

Purpose: The current study examined whether age-related changes in left ventricular (LV) longitudinal systolic function is an adaptation to a more sedentary lifestyle and can be preserved by lifelong exercise training. Methods: A cross-sectional examination of 18 sedentary young (37+/-6 years), 29 sedentary seniors (71+/-5 years, 0-3 exercise sessions/wk), and 26 seniors (68+/-5 years) who had performed a committed level (4-7 exercise sessions/wk) of lifelong (>25 years) exercise. Invasive right heart catheterization (pulmonary capillary wedge pressure) and non-invasive measures of LV function were collected at the following conditions: 1) supine rest, 2) during LV unloading (lower body negative pressure), and 3) LV loading (saline infusion). Ejection fraction (EF) and preload-recruitable stroke work (PRSW) were used to describe global LV systolic function, while peak systolic tissue velocity (S') and longitudinal strain (LS) indicate LV longitudinal systolic function. To adjust LS for aging and training-related differences in LV preload and afterload, LV end-diastolic volume and end-systolic pressure (ESP) were included as covariates in ANCOVA models. Results: EF and PRSW were unaffected by aging or lifelong exercise (P=0.22, P=0.08, respectively). S' decreased with aging (P

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