Contralateral Repeated Bout Effect of the Knee Flexors.

Purpose: Eccentric exercise of the elbow flexors (EF) confers protective effect against muscle damage of the same exercise performed by the opposite arm at 1, 7 or 28 days later. This is known as the contralateral repeated bout effect (CL-RBE), but it is not known whether CL-RBE is evident for the knee flexors (KF). The present study tested the hypothesis that KF CL-RBE would be observed at 1, 7 and 28 days after the initial bout. Methods: Young untrained men were assigned to a control or one of three experimental groups (n=13/group). The experimental groups performed 60 maximal KF eccentric contractions (60MaxEC) by one leg followed 1 (1d), 7 (7d) or 28 days (28d) by 60MaxEC using the opposite leg. The control group used the non-dominant leg to repeat 60MaxEC separated by 14 days. Changes in several indirect muscle damage markers after 60MaxEC were compared between bouts and among the groups by mixed-design two-way ANOVAs. Results: Changes in maximal voluntary isokinetic concentric contraction torque, range of motion, muscle soreness, and plasma creatine kinase activity after the first 60MaxEC were similar among the groups. These changes were smaller after the second than the first 60MaxEC for the control, 1d and 7d groups, and the changes after the second 60MaxEC were smaller for the control than both 1d and 7d groups (P

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