Early corticospinal tract damage in prodromal SCA2 revealed by EEG-EMG and EMG-EMG coherence

SCA2 is caused by a polyglutamine-coding CAG trinucleotide repeat expansion (>34) in the ataxin-2 gene (Pulst et al., 1996). The complex SCA2 phenotype results from multi-system degeneration, involving cerebellum, spinal cord, brainstem and thalamus (Rüb et al., 2013). The prodromal stage of SCA2 was defined here according to Maas et al. (2015) as individuals with already detectable central and/or peripheral nervous system changes but without or with only minimal signs of ataxia (Maas et al., 2015).

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