Immunomodulation of Mesenchymal Stem Cells in discogenic pain

Back pain is a highly prevalent health problem in the world today and has a great economic impact on the healthcare budgets. Intervertebral disc degeneration has been identified as a main cause of back pain. Inflammatory cytokines produced by macrophages or disc cells in an inflammatory environment play an important role in painful progressive degeneration of intervertebral disc. Mesenchymal stem cells (MSCs) have shown to have immunosuppressive and anti-inflammatory properties. MSCs express a variety of chemokines and cytokines receptors having tropism to inflammation sites.

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